By Novartis Foundation
There's an pressing have to discover new remedies that may guard opposed to malaria, because the parasite turns into more and more immune to on hand medicinal drugs and this e-book deals insights into 3 interrelated facets of the malaria-infected erythrocyte:
* The delivery of solutes into and out of the contaminated phone and using particular trafficking pathways in drug targeting
* The site visitors of proteins produced by means of the intracellular parasite as a necessary strategy for the biogenesis of shipping systems.
* the connection among the shipping of gear into the contaminated mobile and the mode of drug motion and drug resistance.
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Additional resources for Novartis Foundation Symposium 226 - Transport and Trafficking in the Malaria-Infected Erythrocyte
50. 46 LEM & HOCKADAY FIG. 3. Comparative electron densities of erythrocyte cytoplasms in Plasmodiumfalciparuminfected and uninfected erythrocytes. falciparum strain from Thailand (Thai Thong & Beak 1981) (courtesy of B. Elford and D. Ferguson). This section is representative of 105 serial sections obtained as part of a different study. The purpose of this figure is to provide an approximate visual estimate of the haemoglobin concentration in erythrocyte cytosols assumed to be reflected in their electron densities.
Other implications from [Hb] conservation are: (i) that gradual host cell swelling leading to osmotic lysis cannot be part of the mechanism of merozoite release; FIG. 2. Predicted time-dependent variations in selected homeostatic variables of Plasmodizlm falciparzlm-infected erythrocytes. The predictions were derived from an homeostatic model developed ad hoc. Parasite growth was simulated by an exponential function of time from t = 0 at time of invasion to 48 h. Parasite volume growth was from 4 to 80% volume occupancy of the host erythrocyte with an equivalent reduction in host cell cytoplasmic volume.
Reliable determination of the transbiiayer disposition of native phospholipids should be based on non-invasive techniques, (prothrombinase activity [Song et a1 19921 or annexin V binding [Henszen et a1 1997]), so far available only for phosphatidylserine. g. using phospholipases) require considerable caution in the application to modified membranes (Schneider et a1 1986). 24 DEUTICKE @ PROTECTION (%) AGAINST LYSlS 100 S R ST. 0 (kD) FIG. 1 . Twoexamples ofthecharacterizationofmembraneporesizesinmodifiederythrocytesby theosmotic protection technique.