By Joseph Marr, Tim W. Nilsen, Richard W. Komuniecki
A priceless, new resource, Molecular clinical Parasitology is the one textual content of its sort -- person who applies large suggestions and present medical advances from either molecular biology and biochemistry to the examine of parasitic organisms. An the world over well known group of scientists and physicians locations parasites of their large organic contexts whereas nonetheless emphasizing the specifics that differentiate those organisms. not just will researchers and school in parasitology locate this an fundamental consultant, physicians will enjoy the thorough assurance molecular biology and biochemistry's present affects on therapy and administration of parasitic diseases.
* positive aspects the main updated medical equipment in the back of the scientific administration of parasitic diseases
* Applies the most up-tp-date synthesis of molecular biology and biochemistry to parasitic organisms
* comprises many informative figures and transparent illustrations
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Proc. Natl. Acad. Sci. USA 96, 2902–2906. , Whitton, C. and The Filarial Genome Project (2001). Trans. Roy. Soc. Hygiene Trop. Med. 96, 1–11. L. (1998). Science 282, 2041–2046. , Guiliano, D. and The Filarial Genome Project (1999). Parasitology 118, S39–S51. The C. elegans Genome Sequencing Consortium (1998). Science 282, 2012–2018. A. A. (1999). Parasitology 118, S19–S38. MOLECUL AR BIOLOGY This Page Intentionally Left Blank C H A P T E R 2 RNA processing in parasitic organisms: trans-splicing and RNA editing Jonatha M.
Blaxter, unpublished observations). THE PARASITES AND THEIR GENOMES The ﬁeld of parasite genomics is rapidly changing. The speed with which genome data can be acquired will make any simple review of the current state of parasite genomics date rapidly. Therefore, below I have indicated the status of the genome projects, the sorts of data available, and highlighted some of the striking research ﬁndings that have already emerged. Each parasite genome project has developed databases to display and analyse its data.
After an exhaustive search for additional ‘intact’ copies of the coxII gene, they concluded that the extra nucleotides were added at the RNA level via an unknown ‘editing’ process. With acceptance of this unorthodox idea came insights into other previously unexplained mysteries of mitochondrial gene expression, such as the apparent use of an altered genetic code in plant mitochondria. Examination of plant mitochondrial (and chloroplast) mRNAs showed that they also differed in speciﬁc ways from the genes from Bloodstream stage: 12S 9S ND8 ND7 which they were transcribed, but in this case the differences were due to cytidine (C) to uridine (and more rarely U to C) changes rather than alterations in overall mRNA length.