Download Alternative Splicing and Disease (Progress in Molecular and by Philippe Jeanteur PDF

By Philippe Jeanteur

Splicing of basic RNA transcript is a quasi-systematic step of gene expression in better organisms. this is often the 1st ebook to spotlight the clinical implications, i.e. illnesses, because of substitute splicing. replacement splicing not just tremendously raises protein range but in addition deals various possibilities for aberrant splicing occasions with pathological effects. The publication additionally outlines attainable objectives for remedy.

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Am J Hum Genet 70: 358–368 Frey UH, Nuckel H, Dobrev D, Manthey I, SAndalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W (2005) Quantification of G protein Gαs subunit splice variants in different human tissues and cells using pyrosequencing. Gene Expression, 12: 69–81 Garcia-Blanco MA, Baraniak AP, Lasda EL (2004) Alternative splicing in disease and therapy. Nat Biotechnol 22: 535–546 Development of quantitative reverse transcriptase PCR assays for measuring gene expression. Methods Mol Biol 291: 423–445 Godfrey TE, Kelly LA (2005) Development of quantitative reverse transcriptase PCR assays for measuring gene expression.

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Presentation at CHI Molecular Medicine Tri-Conference April 19–25 Brooks H, Krahenbuhl S (2001) Identification and tissue distribution of two differentially spliced variants of the rat carnitine transporter OCTN2. FEBS Lett 508: 175–180 Brunet JP, Tamayo P, Golub TR, Mesirov JP (2004) Metagenes and molecular pattern discovery using matrix factorization. Proc Natl Acad Sci U S A 101: 4164–4169 Bruno IG, Jin W, Cote GJ (2004) Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements.

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