Download Advances in Immunology, Vol. 31 by Henry G. Kunkel (ed.), Frank J. Dixon (ed.) PDF

By Henry G. Kunkel (ed.), Frank J. Dixon (ed.)

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Extra resources for Advances in Immunology, Vol. 31

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1978). The same results were found by Miller 34 EMIL R . 4. This experiment shows the induction of suppressor T cells by incubation of macrophage-depleted spleen cells with copolymer L-glutamic acid-L-alanine-L-tyrosine (GAT). Unfractionated or nonadherent spleen cells were cultured for 2 days with the antigens indicated in the graph. The “educated” cells were then added to fresh cultures of syngeneic spleen cells stimulated with GAT. Cells cultured in the absence of adherent cells with 10 Fg of GAT generated suppressor activity.

An important component of macrophage activation is also found in the response to tumors. Delayed-type hypersensitivity and contact sensitivity reactions are expressions of cellular immunity reactions to protein antigens or contact sensitizers deposited in the skin. These reactions involve immune T cells that, by way of various soluble mediators, call forth and activate macrophages . The activated macrophages are bone marrow-derived MACROPHAGES I N ANTIGENIC STIMULATION 39 phagocytes that have changed their biology, developing a heightened cytocidal activity.

UNANUE cytes were harvested and transferred to various inbred strains syngeneic or allogeneic with the donor of the cells. , 1975) was taken as a measure of delayed sensitivity. The basic results of their experiments were that the sensitized T cells could transfer the reaction to syngeneic, but not to allogeneic, recipients; furthemiore, using recipient mice from inbred strains sharing part of the H-2, it was found that successful transfer required identity at I-A subregion between the donor and recipient strains of mice.

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