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By Leopold G. Koss and Dulcie V. Coleman (Auth.)

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Note complex convolution of lateral plasma membranes near the basal lamina (arrow). 15 Well differentiated, invasive adenocarcinoma of endometrium. (a) The ultrastructural alterations are essentially similar to those of carcinoma in situ cells. Despite invasion of smooth muscle cells (M) of the myometrium, the neoplastic gland cells produce a well formed basal lamina (arrow), (x 5,200 reduced to 85%) (b) Scanning electron micrograph. Note cellular pleomorphism, short and sparse surface microvilli, a few ciliated cells and collapsed surface plasma membranes.

References 1. HERTIG, A. T. c. (1949) Genesis of endometrial carcinoma. I. Study of prior biopsies, Cancer, 2, 946-956 2. MCBRIDE, J. M. (1959) The functional activity of the genital tract in postmenopausal endometrial carcinoma, Journal of Obstetrics and Gynaecology of the British Empire, 66, 288-296 3. GREENE, R. , RODDICK, J. W. JR a n d MILLIGAN, M. ( 1 9 5 8 ) Estrogens, endometrial hyperplasia and endometrial cancer, Annals of the New York Academy Sciences, 75, 586-599 4. BEUTLER, H. , DOCKERTY, M.

The specimen should be presented to the pathologist in such a way as to ensure precise preservation of cell morphology. Finally, the procedure should be quick and uncomplicated so as to be practicable for use in a busy clinic. Many techniques for sampling the endometrium have been devised and tested in an outpatient setting. The majority involved the collection of specimens for cytological analysis and a small number have been designed primarily for endometrial biopsy for histological processing.

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